Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders.
Identifieur interne : 002B81 ( Main/Exploration ); précédent : 002B80; suivant : 002B82Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders.
Auteurs : Gloria Lee [Canada] ; Reina BendayanSource :
- Pharmaceutical research [ 0724-8741 ] ; 2004.
English descriptors
- KwdEn :
- AIDS Dementia Complex (metabolism), Alzheimer Disease (metabolism), Animals, Blood-Brain Barrier (metabolism), Blood-Brain Barrier (ultrastructure), Brain (metabolism), Brain Neoplasms (metabolism), Central Nervous System Diseases (drug therapy), Central Nervous System Diseases (etiology), Central Nervous System Diseases (metabolism), Drug Resistance, Multiple, Humans, P-Glycoprotein (metabolism), Parkinson Disease (metabolism).
- MESH :
- chemical , metabolism : P-Glycoprotein.
- drug therapy : Central Nervous System Diseases.
- etiology : Central Nervous System Diseases.
- metabolism : AIDS Dementia Complex, Alzheimer Disease, Blood-Brain Barrier, Brain, Brain Neoplasms, Central Nervous System Diseases, Parkinson Disease.
- ultrastructure : Blood-Brain Barrier.
- Animals, Drug Resistance, Multiple, Humans.
Abstract
The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.
PubMed: 15359566
Affiliations:
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Le document en format XML
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first="Reina" last="Bendayan">Reina Bendayan</name></author></analytic><series><title level="j">Pharmaceutical research</title><idno type="ISSN">0724-8741</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS Dementia Complex (metabolism)</term><term>Alzheimer Disease (metabolism)</term><term>Animals</term><term>Blood-Brain Barrier (metabolism)</term><term>Blood-Brain Barrier (ultrastructure)</term><term>Brain (metabolism)</term><term>Brain Neoplasms (metabolism)</term><term>Central Nervous System Diseases (drug therapy)</term><term>Central Nervous System Diseases (etiology)</term><term>Central Nervous System Diseases (metabolism)</term><term>Drug Resistance, Multiple</term><term>Humans</term><term>P-Glycoprotein (metabolism)</term><term>Parkinson Disease (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>P-Glycoprotein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Central Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Central Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>AIDS Dementia Complex</term><term>Alzheimer Disease</term><term>Blood-Brain Barrier</term><term>Brain</term><term>Brain Neoplasms</term><term>Central Nervous System Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Blood-Brain Barrier</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Resistance, Multiple</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Bendayan, Reina" sort="Bendayan, Reina" uniqKey="Bendayan R" first="Reina" last="Bendayan">Reina Bendayan</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Lee, Gloria" sort="Lee, Gloria" uniqKey="Lee G" first="Gloria" last="Lee">Gloria Lee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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